TAIWANESE STUDY OF MUCINOUS APPENDIX CANCER

Clinicopathologic Features and Predictors for Survival of Mucinous and Nonmucinous Appendiceal Adenocarcinoma
Jun-Te Hsu^a, Han-Ming Chen^b, Chien-Hung Liao^a, Chun-Nan Yeh^a, Ta-Sen Yeh^a, Tsann-Long Hwang^a, Yi-Yin Jan^a, Miin-Fu Chen^a

Departments of Surgery,
^aChang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, and
^bChung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan, ROC

Address of Corresponding Author

Dig Surg 2008;25:369-375 (DOI: 10.1159/000170880)

 

Abstract

Background/Aims: We report a study in patients with mucinous and nonmucinous appendiceal adenocarcinoma treated surgically whose records were examined to elucidate their clinicopathologic features and prognostic factors for survival. Methods: The medical records of 34 patients with mucinous and nonmucinous appendiceal adenocarcinoma (1991-2005) were retrospectively reviewed. Results: There was no significant difference between mucinous and nonmucinous tumors in patient demographics, clinicopathologic features, type of operation and outcome. Nonmucinous tumors had a higher incidence of leukocytosis than mucinous ones. The overall 5-year survival rate for 34 patients with appendiceal adenocarcinoma was 35.8%. In the univariate analysis, predictors of survival were the type of operation, resectability, carcinomatosis and tumor stage. Tumor stage significantly influenced patient survival in the multivariate analysis. Conclusion: Mucinous appendiceal adenocarcinoma had clinicopathologic characteristics and a prognosis similar to nonmucinous, except that there was more leukocytosis in nonmucinous tumors. Tumor stage is an independent predictor for survival among patients with appendiceal adenocarcinoma.

Copyright © 2008 S. Karger AG, Basel

Table 5. Prognostic factors and 5-year survival of appendiceal adenocarcinoma in the literature

Fig. 2. Cumulative survival of mucinous and nonmucinous adenocarcinoma of the appendix in terms of disease stage.

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[Karolyn]

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